高志增
副教授/副研究员
单位:海洋生物天然产物研究所 行政职务:
学科专业:海洋化学 专业技术资格/导师:副教授/博士生导师
办公电话:  
电子邮箱:gaozhizeng@mail.sysu.edu.cn
通讯地址:广东省广州市番禺区中山大学东校区南实验楼E203

 

高志增,本科毕业于山东大学。20082013年在加拿大阿尔伯塔大学John Vederas 教授课题组(英国皇家院士,Fellow of the Royal Society)攻读博士学位,主要研究天然产物的生物合成,在JACS, Nature Chem Bio等期刊发表论文多篇。2013年,加入英属哥伦比亚大学Steve Withers 教授组(英国皇家院士,Fellow of the Royal Society),从事博士后研究。在博后期间发展了多种流感病毒神经氨酸酶荧光探针(Angew 2017, Angew 2018US Patent 16/257,920)。之后发展了“FP tag”高通量糖基转移酶活性测试方法,并通过高通量筛选发现了两个海洋来源的Kdo 糖基转移酶抑制剂(JACS 2019)。之后和加拿大医药研究中心(CDRD)合作,筛选了一个包含15万化学物的商业化合物库,找出多个Kdo 糖基转移酶抑制剂。2018年,加入中山大学海洋学院,主要的研究方向是海洋天然产物的基因挖掘以及其药物化学应用。现在课题组招聘具有天然产物,分子生物学,化学生物学, 有机合成,糖化学等背景的博士后和专职科研人员多名,如有意向,请发简历至gaozhizeng@mail.sysu.edu.cn!如果有对海洋天然产物,药物化学等感兴趣的本科同学,也欢迎加入我们课题组!

 

Representative Publication

  1. Zhizeng Gao*, Olga G. Ovchinnikova, Bo Shun Huang, Dave Williams, Feng Liu, Todd Lowary, Chris Whitfield, Raymond J Andersen and Stephen G Withers*. A High-Throughput “FP-Tag” Assay for the Identification of Glycosyltransferase Inhibitors. Journal of the American Chemical Society, 2018, In Press (*co-corresponding author)
  2. Zhizeng Gao, Andrew J. Thompson, James C. Paulson and Stephen G. Withers. Proximity Ligation-Based Fluorogenic Imaging Agents for Neuraminidases.  Angewandte Chemie International Edition, 2018, 57, 13538-13541 (VIP paper)
  3. Zhizeng Gao, MasaHiro Niikura, Stephen G. Withers. Ultrasensitive Fluorogenic Reagents for Neuraminidase Titration.  Angewandte Chemie International Edition, 2017, 56, 6112-6116
  4. Ralph A. Cacho, Justin Thuss, Wei Xu, Randy Sanichar, Zhizeng Gao, Allison Nguyen, John C. Vederas, and Yi Tang. Understanding Programming of Fungal Iterative Polyketide Synthases: the Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin LovB Megasynthase. Journal of the American Chemical Society, 2015, 135, 15688–15691. 
  5. Rachel V. K. Cochrane#, Zhizeng Gao#, Gareth R. Lambkin, Wei Xu, Jaclyn M. Winter, Sandra L. Marcus, Yi Tang,and John C. Vederas. Comparison of 10,11-Dhydrocurvularin polyketide synthases from Alternaria cinerariae and Aspergillus terreus highlights key structural motifs. ChemBioChem, 2015, 16, 2479-2483 (#equal contribution, VIP paper)
  6. S.-H. Sheldon Tai, Olga Agafitei, Zhizeng Gao, Richard Liggins, Stephen G. Withers, Masahiro Niikura. Difluorosialic acid, a potent novel influenza virus neuraminidase inhibitor, induces fewer drug-resistant neuraminidase mutations than Oseltamivir. Virus Research, 2015, 210, 126-132
  7. Zhizeng Gao#, Jingjing  Wang#, Amy K. Norquay, Kangjian Qiao, Yitang, John C. Vederas. Investigation of fungal iterative polyketide synthase functions using partially assembled intermediates. Journal of the American Chemical Society, 2013, 135, 1735-1738 #equal contribution, featured in JACS spotlight)
  8. Bryan Pyle, Hue Tran, Benjamin Pickel; Tegan Haslam; Zhizeng Gao, Gillian MacNevin, John C. Vederas, Dae-Kyun Ro. Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis). FEBS Journal, 2012, 279, 3136-3146
  9. Hui Zhou#, Zhizeng Gao#, Kangjian Qiao, Jingjing Wang, John C. Vederas, Yi Tang.  A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nature Chemical Biology, 2012, 8, 331-333 (#equal contribution, Cover Story)
  10. Hui Zhou#, Kangjian Qiao#, Zhizeng Gao#, John C. Vederas, Yi Tang.  Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. Journal of Biological Chemistry, 2010, 285, 41412-41421. (#equal contribution)
  11. Hui Zhou, Kangjian Qiao, Zhizeng Gao, Michael J. Meehan, Jesse W.-H. Li, Xiling Zhao, Pieter C. Dorrestein, John C. Vederas, Yi Tang. Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. Journal of the American Chemical Society, 2010, 132, 4530-4531

 

Patent

    Zhizeng Gao, Stephen G. Withers. Compositions and methods for neuraminidase detection and quantification. US Patent application number: 16/257,920