高志增
副教授/副研究员
单位:海洋生物天然产物研究所 行政职务:
学科专业:海洋化学 专业技术资格/导师:副教授/博士生导师
办公电话:  
电子邮箱:gaozhizeng@mail.sysu.edu.cn
通讯地址:广东省广州市番禺区中山大学东校区南实验楼E203
 
 

研究方向

海洋天然产物生物合成

招生专业

海洋化学

个人详细介绍

 

 

Professional Experiences

Associate Professor, Sun Yet-san University                                  Feb. 2018 – Present

 

Michael Smith Postdoctoral Fellow with Prof. Stephen Withers      Sept. 2013 – Feb. 2018

University of British Columbia, Vancouver, BC                                          

 

Education

Ph.D. Bioorganic Chemistry with Prof.John Vederas                   Sept. 2008 – Aug. 2013

University of Alberta, Edmonton, AB                                                      

 

B.Sc. in Chemistry and B.Eng. in Chemical Engineering,           Sept. 2003– Aug. 2008

with Prof. Deliang Cui,  Shandong University, Jinan, Shandong                                                        

 

Awards

2013-2015: Michael Smith Postdoctoral Fellowship

2013: Faculty of Science Dissertation Award(University of Alberta)

2013: FGSRGraduate Teaching Award (University of Alberta)

2012: Graduate Research Award (University of Alberta)

2006: ExcellentStudent Scholarship (Shandong University)

2005: ExcellentStudent Scholarship (Shandong University)

 

Representative Publication

 

1.      Zhizeng Gao,MasaHiro Niikura, Steve Withers. Ultrasensitive Fluorogenic Reagents for NeuraminidaseTitration.  Angewandte Chemie International Edition, 2017, 56, 6112-6116

2.      RachelV. K. Cochrane1, Zhizeng Gao1,Gareth R. Lambkin, Wei Xu, Jaclyn M. Winter, Sandra L. Marcus, Yi Tang,and JohnC. Vederas. Comparison of 10,11-Dhydrocurvularin polyketide synthases from Alternaria cinerariae and Aspergillus terreus highlights keystructural motifs. ChemBioChem, 2015, 16, 2479-2483 (1equal contribution,VIP paper)

3.      Zhizeng Gao1,Jingjing  Wang1, Amy K. Norquay, KangjianQiao, Yitang, John C. Vederas. Investigation of fungal iterative polyketidesynthase functions using partially assembled intermediates. Journal of the American Chemical Society,2013, 135, 1735-1738(1equal contribution,featured in JACS spotlight)

4.       Hui Zhou1, Zhizeng Gao1, Kangjian Qiao, Jingjing Wang, John C.Vederas, Yi Tang. A fungalketoreductase domain that displays substrate-dependent stereospecificity. Nature ChemicalBiology, 2012,8, 331-333(1equal contribution, Cover Story)

5.       Hui Zhou1,Kangjian Qiao1, Zhizeng Gao1, John C. Vederas, Yi Tang.  Insights into radicicol biosynthesis viaheterologous synthesis of intermediates and analogs. Journal of Biological Chemistry, 2010, 285, 41412-41421. (1equal contribution)

6.      Hui Zhou, Kangjian Qiao, Zhizeng Gao, Michael J. Meehan, JesseW.-H. Li, Xiling Zhao, Pieter C. Dorrestein, John C. Vederas, Yi Tang.Enzymatic synthesis of resorcylic acid lactones by cooperation of fungaliterative polyketide synthases involved in hypothemycin biosynthesis. Journal of the American Chemical Society,2010, 132, 4530-4531