本课题组长期招收博士后,欢迎优秀人才加盟!

(一)课题组基本情况

本课题组负责人为中山大学海洋科学学院李朝政副教授,博士生导师,广东省杰出青年基金获得者,“广东特支计划”科技创新青年拔尖人才项目获得者,以第一作者或通讯作者发表SCI论文20余篇,主持国家及省部级等项目10余项,授权发明专利2项,联合培育国家新品种2项。课题组主要以对虾为材料,开展对虾基础免疫学及遗传育种相关研究。具体研究工作为对虾免疫系统的解析;对虾免疫系统与病原(细菌及病毒)之间的相互作用机制研究;对虾经济性状的分子标记开发、遗传育种模型建立、新品种及新品系的选育。在对虾基础免疫学研究方面,课题组在解析对虾Toll和IMD信号通路、对虾核酸诱导免疫激活通路(STING/IRF/Vago/JAK-STAT)调控机制方面以及对虾免疫系统与细菌和白斑综合症病毒互作机制方面取得了一些重要的研究进展,共发表SCI论文40余篇,代表性的成果发表于PLoS Pathogens, Scientific Reports, Developmental and Comparative Immunology, Fish and Shellfish Immunology, FEBS Letters, Molecular Immunology等杂志上;在对虾遗传育种方面,课题组从凡纳滨对虾基因组及转录组中筛选及鉴定了1万多个高多态性的SSR分子标记,利用分子标记建立了辅助育种技术,授权2项国家发明专利,联合广东恒兴饲料实业股份有限公司,广东海兴农集团有限公司培育了“中兴1号”、“海兴农2号”两个凡纳滨对虾国家新品种。

(二课题组负责人教育及工作经历

1. 2018-08-至今:中山大学,海洋科学学院,副教授,博士生导师;

2. 2015/08 – 2018-07:中山大学,海洋科学学院,特聘研究员;

3. 2013/06 – 2015/07:中山大学,生命科学学院,博士后(合作导师:林浩然院士)

4. 2008/09 – 2013/06:中山大学,生命科学学院,海洋生物学专业,博士(硕博连读,导师:何建国教授);

5. 2004/09 – 2008/06:中南林业科技大学,生命科学学院,生物技术专业,学士。

(三)主持及参与的科研项目

主持项目

1. 2018年“蓝色粮仓科技创新”重点专项-“池塘和工厂化养殖对典型环境胁迫的响应机制和预警模型构建”-子任务;96万;

2. 2018年“蓝色粮仓科技创新”重点专项-“ 病原诱导的先天免疫信号通路与调控网络”-子任务;41万;

3. 2018年广东省科技创新战略专项资金(重点领域研发计划)-“抗病优质凡纳滨对虾分子设计育种技术研发及新品种培育”-子课题;210万;

4. 国家自然科学基金-面上项目(小额探索):对虾STING介导的胞质DNA识别与应答的分子机制,25万;

5. 广东省特支计划青年拔尖人才项目:30万;

6. 广东省自然科学基金杰出青年基金:对虾中核酸诱导抗病毒免疫反应的分子机制,100万;

7. 国家自然科学基金-青年科学基金项目:白斑综合症病毒对凡纳滨对虾NF-κB调控的分子机制,25万

8. 广东省海洋与渔业局项目:凡纳滨对虾SSR分子标记辅助育种设计,50万;

9. 高校基本科研业务费中山大学青年教师培育项目:环境胁迫诱发白斑综合症爆发的分子机制,15万;

10. 中国博士后科学基金-面上资助项目(第55批):凡纳滨对虾IRFLvIRF)基因克隆、鉴定及功能研究,5万

11. 广州市科技计划重点项目:“重要鱼虾养殖种类分子育种关键技术研究”-子课题,60万。

参与项目

12. 国家自然科学基金面上项目:凡纳滨对虾Vago信号通路的调控机制及其在抗病毒免疫中的作用,78万;

13. 国家自然科学基金青年基金:鲈鱼RLRs信号通路在鱼类神经坏死病毒感染过程中的作用机制研究,25万;

14. 农业部“引进国际先进农业科学技术”项目:中南美洲农业生物资源引进与农业技术需求和政策信息收集研究,200万;

15. 广东省水产良种体系建设方向项目:南美白对虾良种选育,80万;

16. 中国 - 东盟海上合作基金项目:中国-东盟海水养殖技术联合研究与推广中心,3641.41万;

17. 国家自然科学基金重点项目:凡纳滨对虾白斑综合症生物防控机理,260万;

18. 国家虾产业技术体系项目(2011-2016),500万;

19. 广东省-厄瓜多尔对虾养殖技术联合推广中心,50万。

(四代表性论文

  1. RNAi screening identifies a new Toll from shrimp Litopenaeus vannamei that restricts WSSV infection through activating Dorsal to induce antimicrobial peptides. PLoS Pathogens 2018. Haoyang Li, Bin Yin, Sheng Wang, Qihui Fu, Bang Xiao, Kai Lv, Jianguo He*, Chaozheng Li* (* Corresponding author).
  2. WSSV–host interaction: Host response and immune evasion (Review). Fish & Shellfish Immunology 2019. Chaozheng Li, Shaoping Weng, Jianguo He* (* Corresponding author).
  3. The c-Fos and c-Jun from Litopenaeus vannamei play opposite roles in Vibrio parahaemolyticus and white spot syndrome virus infection. Developmental and Comparative Immunology 2015 52:26–36. Chaozheng Li*, Haoyang Li, Sheng Wang, Xuan Song, Zijian Zhang, Zhe Qian, Hongliang Zuo, Xiaopeng Xu, Shaoping Weng, Jianguo He * (* Corresponding author)
  4. Shrimp with knockdown of LvSOCS2, a negative feedback loop regulator of JAK/STAT pathway in Litopenaeus vannamei, exhibit enhanced resistance against WSSV. Developmental and Comparative Immunology 2016 65:289-298. Sheng Wang, Xuan Song, Zijian Zhang, Haoyang Li, Kai Lǚ, Bin Yin, Jianguo He*, Chaozheng Li* (* Corresponding author)
  5. Shrimp TAB1 interacts with TAK1 and p38 and activates the host innate immune response to bacterial infection. Molecular Immunology 2017 88:10-19. Sheng Wang, Mengqiao Li, Bin Yin, Haoyang Li, Bang Xiao, Kai Lǚ, Zhijian Huang, Sedong Li, Jianguo He⁎, Chaozheng Li⁎  (* Corresponding author)
  6. Presence of Tube isoforms in Litopenaeus vannamei suggests various regulatory patterns of signal transduction in invertebrate NF-kB pathway. Developmental and Comparative Immunology 2014 42: 174–185. Chaozheng Li, Yixiao Chen, Shaoping Weng, Sedong Li, Hongliang Zuo, Xiaoqiang Yu, Haoyang Li, Jianguo He *, Xiaopeng Xu * (* Corresponding author)
  7. Pellino protein from pacific white shrimp Litopenaeus vannamei positively regulates NF-kB activation. Developmental and Comparative Immunology 2014 44(2):341-50. Chaozheng Li, Jiaoting Chai, Haoyang Li, Hongliang Zuo, Sheng Wang, Wei Qiu, Shaoping Weng, Jianguo He*, Xiaopeng Xu* (* Corresponding author)
  8. Molecular cloning, expression, promoter analysis and functional characterization of a new Crustin from Litopenaeus vannamei. Fish & Shellfish Immunology 2018. Ming Lia, Chunxia Ma, Haoyang Li, Jinxia Peng, Digang Zeng, Xiaohan Chen, Chaozheng Li (* Corresponding author)
  9. MKK6 from pacific white shrimp Litopenaeus vannamei is responsive to bacterial and WSSV infection. Molecular Immunology 2016 70: 72–83. Haoyang Li, Sheng Wang, Yonggui Chen, Kai Lǚ, BinYin, Sedong Li, Jianguo He *, Chaozheng Li * (* Corresponding author)
  10. MKK4 from Litopenaeus vannamei is a regulator of p38 MAPK kinase and involved in anti-bacterial response. Developmental and Comparative Immunology 2018 78:61-70.  Sheng Wang, Bin Yin, Haoyang Li, Bang Xiao, Kai Lǚ, Chiguang Feng, Jianguo He*, Chaozheng Li* (* Corresponding author)
  11. Identification, Characterization, and Function Analysis of the Cactus Gene from Litopenaeus vannamei. Plos One 2012 7(11):e49711. Chaozheng Li, Yi-Xiao Chen, Shuang Zhang, Ling Lu, Yi-Hong Chen, Jiaoting Chai, Shaoping Weng, Yong-Gui Chen, Jianguo He*, Xiaopeng Xu*  (* Corresponding author)
  12. Identification of a JAK/STAT pathway receptor domeless from Pacific white shrimp Litopenaeus vannamei. Fish & Shellfish Immunology 2015.  Muting Yan, Chaozheng Li, Ziqi Su, Qianhui Liang, Haoyang Li, Shizhong Liang, Shaoping Weng, Jianguo He, *, Xiaopeng Xu*  (* Corresponding author)
  13. Identification of a C-type lectin with antiviral and antibacterial activity from pacific white shrimp Litopenaeus vannamei. Developmental and Comparative Immunology 2014. Ming Li, Chaozheng Li, Chunxia Ma, Haoyang Li, Hongliang Zuo, Shaoping Weng, Xiaohan Chen, Digang Zeng, Jianguo He, Xiaopeng Xu (* Corresponding author)
  14. Identification and functional characterization of the TAB2 gene from Litopenaeus vannamei. Fish & Shellfish Immunology 2015 46(2):206-16. Sheng Wang, Haoyang Li, Zhe Qian, Xuan Song, Zijian Zhang, Hongliang Zuo, Xiaopeng Xu, Shaoping Weng, Jianguo He*, Chaozheng Li* (* Corresponding author)
  15. Identification and functional analysis of a TEP gene from a crustacean reveals its transcriptional regulation mediated by NF-κB and JNK pathways and its broad protective roles against multiple pathogens. Developmental and Comparative Immunology 2017 70: 45-58. Chaozheng Li *, Haoyang Li, Bang Xiao, Yonggui Chen, Sheng Wang, Kai Lǚ, Bin Yin, Sedong Li, Jianguo He * (* Corresponding author)
  16. Identification and characterization of transforming growth factor β-activated kinase 1 from Litopenaeus vannamei involved in anti-bacterial host defense. Fish & Shellfish Immunology 2016 52: 278-288. Sheng Wang, Haoyang Li, Kai Lǚ, Zhe Qian, Shaoping Weng, Jianguo He *, Chaozheng Li * (* Corresponding author)
  17. Identification and characterization of MKK7 as an upstream activator of JNK in Litopenaeus vannamei. Fish & Shellfish Immunology 2016 48: 285-294. Sheng Wang, Zhe Qian, Haoyang Li, Kai Lǚ, Xiaopeng Xu, Shaoping Weng, Jianguo He *, Chaozheng Li * (* Corresponding author)
  18. Identifcation of two p53 isoforms from Litopenaeus vannamei and their interaction with NF-κB to induce distinct immune response. Scientific Reports 2017 7:45821. Haoyang Li, Sheng Wang, Yonggui Chen, Kai Lǚ, BinYin, Sedong Li, Jianguo He * & Chaozheng Li * (* Corresponding author)
  19. Cloning, identification and functional analysis of a b-catenin homologue from Pacific white shrimp, Litopenaeus vannamei. Fish & Shellfish Immunology 2016 54:411-8. Shuang Zhang, Lili Shi, Kai Lǚ, Haoyang Li, Sheng Wang, Jianguo He*, Chaozheng Li* (* Corresponding author)
  20. Analysis of Litopenaeus vannamei Transcriptome Using the Next-Generation DNA Sequencing Technique. PLoS ONE 2012 7,10: e47442. Chaozheng Li, Shaoping Weng, Yonggui Chen, Xiaoqiang Yu, Ling Lu, Haiqing Zhang, Jianguo He *, Xiaopeng Xu * (* Corresponding author)
  21. An invertebrate STING from shrimp activates an innate immune defense against bacterial infection. FEBS Letters 2017 591(7):1010-1017. Haoyang Li, Sheng Wang, Kai Lǚ, Bin Yin, Bang Xiao, Sedong Li, Jianguo He *, Chaozheng Li * (* Corresponding author)
  22. Activation of Vago by interferon regulatory factor (IRF) suggests an interferon system-like antiviral mechanism in shrimp. Scientific Reports 2015 5:15078. Chaozheng Li, Haoyang Li, Yixiao Chen, Yonggui Chen, Sheng Wang, Shao-Ping Weng, Xiaopeng Xu *, Jianguo He * (* Corresponding author)
  23. A Janus Kinase in the JAK/STAT signaling pathway from Litopenaeus vannamei is involved in antiviral immune response. Fish & Shellfish Immunology 2015 44: 662-673. Xuan Song, Zijian Zhang, Sheng Wang, Haoyang Li, Hongliang Zuo, Xiaopeng Xu, Shaoping Weng, Jianguo He *, Chaozheng Li * (* Corresponding author)
  24. A C-type lectin (LvCTL4) from Litopenaeus vannamei is a downstream molecule of the NF-kB signaling pathway and participates in antibacterial immune response. Fish & Shellfish Immunology 2015 43(1):257-63. Haoyang Li, Yonggui Chen, Ming Li, Sheng Wang, Hongliang Zuo, Xiaopeng Xu, Shaoping Weng, Jianguo He*, Chaozheng Li* (* Corresponding author)

(五授权发明专利

1. 凡纳滨对虾EST微卫星标记的特异引物及其应用,李朝政,吕玲,张付霞,翁少萍,何建国,授权时间:2012.09,中国,授权专利号:ZL201010259991.7

2. 一种凡纳滨对虾fx5微卫星DNA标记鉴定fx5遗传变异图谱的方法,李朝政,吕玲,翁少萍,何建国,授权时间:2013.05,中国,授权专利号:ZL 201010258780.1