高志增
副教授/副研究员
单位：海洋生物天然产物研究所 行政职务：
学科专业：海洋化学 专业技术资格/导师：副教授/博士生导师
办公电话：  
电子邮箱：gaozhizeng@mail.sysu.edu.cn
通讯地址：中山大学珠海校区

 

高志增，本科毕业于山东大学。2008到2013年在加拿大阿尔伯塔大学John Vederas 教授课题组（英国皇家院士，Fellow of the Royal Society）攻读博士学位，主要研究天然产物的生物合成，在JACS, Nature Chem Bio等期刊发表论文多篇。2013年，加入英属哥伦比亚大学Steve Withers 教授组（英国皇家院士，Fellow of the Royal Society），从事博士后研究。在博后期间发展了多种流感病毒神经氨酸酶荧光探针（Angew 2017, Angew 2018，US Patent 16/257,920）。之后发展了“FP tag”高通量糖基转移酶活性测试方法，并通过高通量筛选发现了多个海洋来源的糖基转移酶抑制剂（JACS 2019）。2018年，加入中山大学海洋学院，主要的研究方向有：

  (1)  海洋天然产物的基因挖掘以及生物合成研究

（2）高效筛选具有抗病毒，抗癌活性的海洋天然产物

（3）海洋酶制剂发掘

 

    现在课题组招聘具有天然产物，分子生物学，化学生物学, 有机合成，糖化学等背景的博士后和专职科研人员多名，如有意向，请发简历至gaozhizeng@mail.sysu.edu.cn! 如果有对海洋天然产物，药物化学等感兴趣的本科同学，也欢迎加入我们课题组！

 

 

Representative Publication

  1. Xinjian, Wenzhong Gong, Zhigeng Zhan, Wei Wei, Mengmeng Li, Jianyu Jiao, Bishuang Chen, Lan Liu, Wenjun Li*, Zhizeng Gao*, Mining and engineering of valine dehydrogenases from a hot spring sediment metagenome for the synthesis of chiral non-natural L-amino acids, Molecular Catalysis, 2022, 533, 112767
  2. Siwen Yuan, Senhua Chen, Heng Guo, Litong Chen, Hongjie Shen, Lan Liu, Zhizeng Gao*. Elucidation of the Complete Biosynthetic Pathway of Phomoxanthone A and Identification of a Para–Para Selective Phenol Coupling Dimerase, Organic Letters, 2022, 24, 3069
  3. Siwen Yuan, Litong Chen, Qilin Wu, Minghua Jiang, Heng Guo, Zhibo Hu, Senhua Chen, Lan Liu, Zhizeng Gao. Genome Mining of α-Pyrone Natural Products from Ascidian-Derived Fungus Amphichordafelina SYSU-MS7908, Marine Drugs, 2022, 20, 294
  4. Xinjian Yin, Yujing Zeng, Jun Chen, Lan Liu, Zhizeng Gao. Combined active pocket and hinge region engineering to develop an NADPH-dependent phenylglycine dehydrogenase, Bioorganic Chemistry, 2022, 105601
  5. Xinjian Yin, Litong Chen, Siwen Yuan, Lan Liu, Zhizeng Gao. A Robust High-throughput Fluorescent Polarization Assay for the Evaluation and Screening of SARS-CoV-2 Fusion Inhibitors, Bioorganic Chemistry, 2021, 116, 105362.
  6. Xinjian Yin, Jiaxin Li, Senhua Chen, Yuping Wu, Zhigang She, Lan Liu, Yue Wang, Zhizeng Gao. An Economical High‐Throughput “FP‐Tag” Assay for Screening Glycosyltransferase Inhibitors, ChemBioChem, 2021, 22, 1391-1395.
  7. Siwen Yuan, Jannu Vinay Gopal, Shuya Ren, Litong Chen, Lan Liu, and Zhizeng Gao. Anticancer Fungal Natural Products: Mechanisms of Action and Biosynthesis, European Journal of Medicinal Chemistry, 2020, 112502
  8. Zhizeng Gao*, Olga G. Ovchinnikova, Bo Shun Huang, Dave Williams, Feng Liu, Todd Lowary, Chris Whitfield, Raymond J Andersen and Stephen G Withers*. High-Throughput “FP-Tag” Assay for the Identification of Glycosyltransferase Inhibitors. Journal of the American Chemical Society, 2019, 141, 2201-2204 (*co-corresponding author)
  9. Zhizeng Gao, Andrew J. Thompson, James C. Paulson and Stephen G. Withers. Proximity Ligation-Based Fluorogenic Imaging Agents for Neuraminidases.  Angewandte Chemie International Edition, 2018, 57, 13538-13541 (VIP paper)
  10. Zhizeng Gao, MasaHiro Niikura, Stephen G. Withers. Ultrasensitive Fluorogenic Reagents for Neuraminidase Titration.  Angewandte Chemie International Edition, 2017, 56, 6112-6116
  11. Zhizeng Gao#, Jingjing Wang#, Amy K. Norquay, Kangjian Qiao, Yitang, John C. Vederas. Investigation of fungal iterative polyketide synthase functions using partially assembled intermediates. Journal of the American Chemical Society, 2013, 135, 1735-1738 （#equal contribution, featured in JACS spotlight)
  12. Hui Zhou#, Zhizeng Gao#, Kangjian Qiao, Jingjing Wang, John C. Vederas, Yi Tang.  A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nature Chemical Biology, 2012, 8, 331-333 (#equal contribution, Cover Story)