一. 教育经历

   2008.9—2012.7 华南农业大学, 理学院, 本科, 学士学位

   2012.9—2017.7 中山大学, 化学学院, 硕博连读, 博士学位，导师：佘志刚 教授

二. 工作经历

   2024.1 - 至今 中山大学 海洋科学学院 副教授 硕士研究生导师

   2017.8 - 2023.12 中山大学 海洋科学学院 特聘副研究员

三.研究方向

主要专注于海洋天然产物化学和海洋药物研发：（1）海洋真菌活性天然产物研究（红树林和珊瑚礁来源真菌，特别是海鞘共附生真菌）；（2）海洋真菌天然产物关键功能酶挖掘；（3）抗肿瘤（尤其是脑胶质瘤）、抗炎、抗心脑血管疾病等海洋药物研发。主持承担了国家自然科学基金面上、青年项目和广东省自然科学基金博士启动项目等，发现的1个候选药物进入临床前研究阶段。相关研究在Nat Prod Rep, Org Lett, Chem Commun, Chin Chem Lett, J Nat Prod等SCI期刊上发表了50余篇论文，google学术引用数1683，H指数26。入选年度全球前2%顶尖科学家榜单（2023, World's Top 2% Scientists）。

四.主持项目

  1. 国家自然科学基金面上项目 (2024-2026)：42376098，51万，海鞘真菌来源chamigrane过氧倍半萜定向挖掘及抗脑胶质瘤作用机制研究。
  2. 国家自然科学基金青年基金项目 (2019-2021)：41806155，25万，基于代谢组指纹信息，挖掘海鞘共附生真菌的抗脑胶质瘤活性化合物。
  3. 广东省自然科学基金博士启动项目 (2018-2020)：2018A030310304，10万，基于化学表观遗传修饰方法对海鞘共附生真菌4729抗脑胶质瘤活性代谢产物的挖掘。
  4. 热带药用资源化学教育部重点实验室2022开放基金(2022-2024)：RDZH2022004，3万，基于分子网络技术挖掘海洋真菌来源环六酯肽化合物研究。

五.授权专利

  1. 陈森华，刘岚，沈鸿杰，姜明华，张盼盼；一种生物碱化合物及其制备方法与应用，201910100289.7，授权日2021-09-28，专利权人：中山大学，授权。
  2. 陈森华，刘岚，陈彬，姜明华，沈鸿杰；一对喹唑啉酮生物碱对映体及其制备方法与应用，200910511662.8，授权日2021-09-24，专利权人：中山大学，授权。
  3. 陈森华，姜明华，刘岚，一种含吡啶的新骨架杂萜类化合物及其制备方法和应用，202011346343.5，授权日2022-03-08，专利权人：中山大学，授权。
  4. 陈森华，刘岚，姜明华, 一种isaridin类环酯肽衍生物及其制备方法和应用，202011346325.7，授权日2022-06-10，专利权人：中山大学，授权。
  5. 陈森华，姜明华, 刘岚，一种海鞘来源真菌及其应用，202011346325.7，授权日2022-06-10，专利权人：中山大学，授权。
  6. 陈森华，刘岚，海葵共附生真菌SYSU-MS5127及其发酵化合物和应用，202011346223.5，授权日2022-11-18，专利权人：中山大学，授权。

六.近五年论文

2023年：

  1. Minghua Jiang#, Senhua Chen#,*, Xin Lu, Heng Guo, Shuihao Chen, Xinjian Yin, Hanxiang Li, Guangyi Dai, Lan Liu*. Integrating Genomics and Metabolomics for the Targeted Discovery of New Cyclopeptides with Antifungal Activity from a Marine-Derived Fungus Beauveria felina. Journal of Agricultural and Food Chemistry, 2023, 71, 25, 9782–9795 (中科院一区top, Cover paper)
  2. Zhenger Wu, Heng Guo, Qilin Wu, Minghua Jiang, Junjie Chen, Bin Chen, Hanxiang Li, Lan Liu, Senhua Chen*. Absolute configuration of cyclopropanes and the structural revision of pyrones from Marine-derived fungus Stagonospora sp. SYSU-MS7888. Bioorganic Chemistry, 2023, 136: 106542. (中科院二区top).
  3. Minghua Jiang, Heng Guo, Qilin Wu, Xin Lu, Yating Zou, Quanyou Fu, Shuihao Chen, Lan Liu, Bo Peng*, Senhua Chen*. Anti-inflammatory acetylenic meroterpenoids from the ascidian-derived fungus Amphichorda felina SYSU-MS7908. Bioorganic Chemistry, 2023: 106715. (中科院二区top).
  4. Minghua Jiang#, Qilin Wu#, Heng Guo, Xin Lu, Shuihao Chen, Lan Liu*, and Senhua Chen* Shikimate-Derived Meroterpenoids from the Ascidian-Derived Fungus Amphichorda felina SYSU-MS7908 and Their Anti-Glioma Activity. Journal of Natural Products, 2023, 86(12): 2651-2660. (中科院二区top, Cover paper)

2022年：

  1. Senhua Chen#, Runlin Cai#, Zhaoming Liu, Hui Cui, Zhigang She*. Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities. Natural Product Reports, 2022, 39(3): 560-595. (中科院一区top，ESI高引).
  2. Siwen Yuan#, Senhua Chen#, Hong Guo, Litong Chen, Hongjie Shen, Lan Liu*, and Zhizeng Gao*. Elucidation of the Complete Biosynthetic Pathway of Phomoxanthone A and Identification of a Para-Para Selective Phenol Coupling Dimerase. Organic Letters, 2022, 24 (16), 3069-3074. (中科院一区top).
  3. Senhua Chen, Heng Guo, Zhenger Wu, Qilin Wu, Minghua Jiang, Hanxiang Li,* and Lan Liu* , Targeted discovery of sorbicillinoid pigments with anti-inflammatory activity from the sponge-derived fungus Stagonospora sp. SYSU-MS7888 using the PMG strategy. Journal of Agricultural and Food Chemistry, 2022, 70, 15116–15125. (中科院一区top, Cover paper)
  4. Senhua Chen, Heng Guo, Minghua Jiang, Qilin Wu, Jing Li, Hongjie Shen, and Lan Liu*. Mono- and Dimeric Xanthones with Anti-Glioma and Anti-Inflammatory Activities from the Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722. Marine Drugs, 2022, 17(9), 522. (中科院二区).

2021年：

  1. Dongni Chen, Lan Liu, Yongjun Lu, Senhua Chen* Identification of fusarielin M as a novel inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB), Bioorganic Chemistry, 2021, 106, 104495. (中科院二区Top).
  2. Heng Guo, Qilin Wu, Dongni Chen, Minghua Jiang, Bin Chen, Yongjun Lu, Lan Liu, and Senhua Chen* Absolute configuration of polypropionate derivatives: Decempyrones A-J and their MptpA inhibition and anti-inflammatory activities, Bioorganic Chemistry, 2021, 106, 104495. (中科院二区Top).
  3. Minghua Jiang, Zhenger Wu, Qilin Wu, Huimin Yin, Heng Guo, Siwen Yuan, Zhaoming Liu, Senhua Chen*, and Lan Liu. Amphichoterpenoids A−C, unprecedented picoline-derived meroterpenoids from the ascidian-derived fungus Amphichorda felina SYSU-MS7908，Chinese Chemical Letters, 2021, 32(6), 1893-1896. (中科院二区).
  4. Minghua Jiang#, Zhenger Wu#, Lan Liu*, Senhua Chen*. Chemistry and Biology of Fungal Meroterpenoids (2009–2019). Organic & Biomolecular Chemistry, 2021, 19, 1644-1704. (Cover paper，ESI高引).
  5. Senhua Chen, Hongjie Shen, Yanlian Deng, Hong Guo, Minghua Jiang, Zhenger Wu, Huimin Yin, Lan Liu*, Roussoelins A and B: Two Phenols with Antioxidant Capacity from Ascidian-Derived Fungus Roussoella siamensis SYSU-MS4723. Marine Life Science & Technology, 2021, 3 (1), 69-76 (中科院二区).

2020年：

  1. Minghua Jiang, Zhenger Wu, Heng Guo, Lan Liu, Senhua Chen*, A review of terpenes from marine-derived fungi: 2015–2019. Marine Drugs, 2020, 18: 321. (中科院二区)
  2. Senhua Chen#, Yanlian Deng#, Chong Yan, Zhenger Wu, Heng Guo, Lan Liu, and Hongju Liu*. Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102. Marine Drugs, 2020, 18: 426. (中科院二区)
  3. Minghua Jiang#, Senhua Chen#,*, Jing Li, Lan Liu*. The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms. Marine Drugs, 2020, 18(2), 114. (中科院二区)

2019年：

  1. Senhua Chen, Hongjie Shen, Panpan Zhang, Hongwei Cheng, Xinliang Dai*, Lan Liu*. Anti-glioma trichobamide A with an unprecedented tetrahydro-5H-furo [2, 3-b] pyrrol-5-one functionality from ascidian-derived fungus Trichobotrys effuse 4729. Chemical Communications, 2019, 55(10): 1438-1441. (中科院一区top)
  2. Panpan Zhang, Yanlian Deng, Xiaojing Lin, Bin Chen, Jing Li, Hongju Liu, Senhua Chen *, and Lan Liu *. Anti-inflammatory Mono-and Dimeric Sorbicillinoids from the Marine-Derived Fungus Trichoderma reesei 4670. Journal of Natural Products, 2019, 82(4): 947-957. (中科院二区top)
  3. Senhua Chen, Minghua Jiang, Bin Chen, Jintana Salaenoi, Shah-Iram Niaz*, Jianguo He and Lan Liu*. Penicamide A, A Unique N,N’-Ketal Quinazolinone Alkaloid from Ascidian-Derived Fungus Penicillium sp. 4829. Marine Drugs, 2019, 17(9), 522. (中科院二区)
  4. Hongjie Shen, Xiaowan Liu, Minghua Jiang, Guangyuan Luo, Zhenger Wu, Bin Chen, Jing Li , Lan Liu * and Senhua Chen*. Anti-Inflammatory Cembrane-Type Diterpenoids and Prostaglandins from Soft Coral Lobophytum sarcophytoides. Marine Drugs, 2019, 17(8): 481. (中科院二区)