陈森华
副教授/副研究员
单位:海洋生物天然产物研究所 行政职务:
学科专业: 专业技术资格/导师:特聘副研究员
办公电话:  
电子邮箱:chensenh@mail.sysu.edu.cn
通讯地址:广州市中山大学东校区南实验楼E203
 
 

研究方向

天然产物化学和化学生物学

招生专业

海洋化学

个人详细介绍

教育经历

2008年9月-2012年6月华南农业大学,应用化学专业,理学学士。

2012年9月-2017年6月中山大学,有机化学专业,理学博士(硕博连读)。

工作经历

2017.8-至今中山大学海洋科学学院特聘副研究员

研究方向

天然产物化学、化学生物学

主持项目

国家自然科学基金青年基金项目:25 万,执行年限:2019.01-2021.12

广东省自然科学基金博士启动项目:10万,执行年限:2018.05-2021.04

代表性论文

Senhua Chen, Meng Ding, Weiyang Liu, Xishan Huang,Zhaoming Liu,Yongjun Lu, Hongju Liu, Zhigang She. Anti-inflammatory meroterpenoids from the mangrove endophytic fungus Talaromyces amestolkiaeYX1. Phytochemistry. 2018,146, 8-15.

Panpan Zhang, Chunxiu Jia, Jiajia Lang, Jing Li, Guangyuan Luo, Senhua Chen * ,Sujun Yan *  and Lan Liu. Mono- and Dimeric Naphthalenones from the Marine-Derived Fungus Leptosphaerulina chartarum 3608. Marine Drugs, 2018, 16(5):173.

Chong Yan, Weiyang Liu, Jing Li, Yanlian Deng, Senhua Chen*, Hongju Liu*. Bioactive terpenoids from Santalum album derived endophytic fungus Fusarium sp. YD-2. RSC Advances, 2018, 8(27): 14823-14828.

Yingnan Wu, Senhua Chen, Yingnan Wu,Senhua Chen,Hongju Liu, Xishan Huang,Yayue Liu, Yiwen Tao, Zhigang She. Cytotoxic isocoumarin derivatives from the mangrove endophytic fungus Aspergillus sp. HN15-5D. Archives of pharmacal research, 2018: 1-6.

Panpan Zhang, Chunxiu Jia, Jiajia Lang, Hongjie Shen, Jing Li, Senhua Chen* and Lan Liu*. Leptothiazinones A and B, two new Benzothiazinones from a marine-derived fungus Leptosphaerulina chartarum 3608. Phytochemistry Letters, 2018, 27:55-58.

Shah-Iram Niaz, Panpan Zhang, Hongjie Shen, Jing Li, Bin Chen, Senhua Chen*, Lan Liu*, Jianguo He. Two new isochromane derivatives penisochromanes A and B from ascidian-derived fungus Penicillium sp. 4829. Natural product research, 2018: 1-7.

Senhua Chen, Zhaoming Liu, Hongju Liu, Yuhua Long, Dongni Chen, Yongjun Lu, Zhigang She*. Lasiodiplactone A, a novel lactone from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1. Org Biomol Chem, 2017, 15, 6338-6341.

Senhua Chen, Liqing He, Dongni Chen, Ruilin Cai, Yuhua Long, Yongjun Lu, and Zhigang She*, Talaramide A, an unusual alkaloid from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1) as Inhibitor of mycobacterial PknG,  New Journal of Chemistry, 2017, 41, 4273-4276.

Panpan Zhang, Yongfang Li, Chunxiu Jia, Jiajia Lang, ShahIram Niaz, Jing Li, Jie Yuan, Jianchen Yu,Senhua Chen* , Lan Liu* Antiviral and anti-inflammatory meroterpenoids: stachybonoids A-F from the crinoid-derived fungus Stachybotrys chartarum 952, RSC Advances, 2017, 7, 49910-49916.

Panpan Zhang, Jing Li, Jiajia Lang, Chunxiu Jia, Shah-Iram Niaz, Senhua Chen*  and Lan Liu*. Two new sesquiterpenes derivatives from marine fungus Leptosphaerulina Chartarum sp. 3608. Natural product research, 2017: 1-7.

Senhua Chen, Dongni Chen, Runlin Cai, Hui Cui, Yuhua Long, Yongjun Lu, Chunyuan Li,  Zhigang She*,Cytotoxic and Antibacterial Preussomerins from the Mangrove Endophytic Fungus Lasiodiplodia theobromae ZJ-HQ1, Journal of natural products, 2016, 79(9): 2397-2402.

Senhua Chen, Yayue Liu, Zhaoming Liu, Runlin Cai, Yongjun Lu, Xishan Huang, Zhigang She*.Isocoumarins and benzofurans from the mangrove endophytic fungus Talaromyces amestolkiae possess α-glucosidase inhibitory and antibacterial activities, RSC Advances, 2016, 6(31): 26412-26420.

Senhua Chen, Zhaoming Liu, Yayue Liu, Yongjun Lu, Lei He, Zhigang She*, New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y2) isolated from the South China Sea,Beilstein journal of organic chemistry, 2015, 11(1): 1187-1193.

Senhua Chen,Zhaoming Liu, Hanxiang Li,Guoping Xia,Yongjun Lu, Lei He, Shaodong Huang, Zhigang She*, bResorcylic acid derivatives withαglucosidase inhibitory activity from Lasiodiplodia sp. ZJHQ1, an endophytic fungus in the medicinal plant Acanthus ilicifolius, Phytochemistry Letters, 2015, 13: 141-146.

Ze’en Xiao, Senhua Chen, Runlin Cai, Shao’e Lin, Kui Hong, Zhigang She*, New furoisocoumarins and isocoumarins from the mangrove endophytic fungus Aspergillus sp. 085242,Beilstein journal of organic chemistry, 2016, 12(1): 2077-2085.

Runlin Cai, Senhua Chen, Yuhua Long, Chunyuan Li, Xishan Huang*, Zhigang She*,Depsidones from Talaromyces stipitatus SK4, an endophytic fungus of the mangrove plant Acanthus ilicifolius. Phytochemistry Letters, 2017, 20: 196-199.  

Zhaoming Liu, Senhua Chen, Pei Qiu, Chunbing Tan, Yuhua Long, Yongjun Lu and Zhigang She.Ascomlactone A, a pair of Novel Dimeric Polyketides from a Mangrove Endophytic Fungus Ascomycota sp. SK2YWS-L.  Organic & Biomolecular Chemistry, 2017.

Yayue Liu, Senhua Chen, Zhaoming Liu, Yongjun Lu, Guoping Xia, Hongju Liu, Lei He, Zhigang She*, Bioactive Metabolites from Mangrove Endophytic Fungus Aspergillus sp. 16-5B, Marine Drugs, 2015, 13(5): 3091-3102.

Hongju Liu, Senhua Chen , Weiyang Liu, Yayue Liu, Xishan Huang, Zhigang She*,Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY2, Marine Drugs, 2016, 14(12): 217.

Runlin Cai, Senhua Chen, Zhaoming Liu, Chunbing Tan, Xishan Huang, Zhigang She.  A new α-pyrone from the mangrove endophytic fungus Phomopsis sp. HNY29-2B. Natural product research, 2016, 31(2):1-7.

Zhaoming Liu, Yan Chen, Senhua Chen, Yayue Liu, Yongjun Lu, Dongni Chen, Yongcheng Lin, Xishan Huang,  Zhigang She*, Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010, Organic Letters, 2016, 18(6): 1406-1409.

Chunbin Tan, Zhaoming Liu, Senhua Chen, Xishan Huang, Hui Cui, Yuhua Long, Yongjun Lu, Zhigang She*, Antioxidative Polyketones from the Mangrove  Derived Fungus Ascomycota sp. SK2YWS-L, Scientific Reports, 2016, 6.

Zhaoming Liu, Guoping Xia, Senhua Chen, Yayue Liu, Hanxiang Li,  Zhigang She*,Eurothiocin A and B, SulfurContaining Benzofurans from a Soft Coral Derived Fungus Eurotium rubrum SH-823, Marine Drugs, 2014, 12(6): 3669-3680.

发明专利

1.      佘志刚陈森华刘昭明刘亚月谭春兵陆勇军何磊,一类海洋真菌来源的缩酚酸类化合物及其治疗II型糖尿病的应用,申请号:201510205871.1,申请日期:2015-04-27,申请授权号:CN104987319A,授权公布日:2017-05-17。

2.      佘志刚陈森华陆勇军陈冬妮黄锡山,海洋真菌来源的萘螺缩酮类化合物及其制备方法和应用,申请号:201610488071.X,申请日期:2016-06-24,申请公开号:106188084A,申请公布日:2016-12-07。