海洋科学学术沙龙第76期：Marine Invertebrates and their Associated-Microorganisms, Untapped Resources for Novel Drug Leads to Treat Metabolic Diseases and Osteoporosi
Marine Invertebrates and their Associated-Microorganisms, Untapped Resources for Novel Drug Leads to Treat Metabolic Diseases and Osteoporosis
Heonjoong Kang 教授任职于首尔国立大学，海洋天然产物与药物发现研究中心，其主要研究方向为海洋天然产物化学、药物化学。
1. Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja. Weihong Wang, Hiyoung Kim, Rahul S Patil, Awadut G Giri, Dong Hwan Won, Dongyup Hahn, Youjung Sung, Jusung Lee, Hyukjae Choi, Sang-Jip Nam, Heonjoong Kang. Bioorganic & medicinal chemistry letters, 2017, 27, 574-577.
2. The Halicylindramides, Farnesoid X Receptor Antagonizing Depsipeptides from a Petrosia sp. Marine Sponge Collected in Korea. Dongyup Hahn, Hiyoung Kim, Inho Yang, Jungwook Chin, Hoosang Hwang, Dong Hwan Won, Byoungchan Lee, Sang-Jip Nam, Merrick Ekins, Hyukjae Choi, and Heonjoong Kang. J Nat. Prod. 2016, 79, 499-506.
3.Synthesis and evaluation of an orally available “Y”-shaped biaryl peroxisome proliferator-activated receptor δ agonist. Dong-Su Kim, Jaehwan Lee, Ashwini M Londhe, Tara Man Kadayat, Jeongmin Joo, Hayoung Hwang, Kyung-Hee Kim, Ae Nim Pae, Jungwook Chin, Sung Jin Cho, Heonjoong Kang. Bioorganic & Medicinal Chemistry, 2018, in press.
Obesity- and bone-related diseases such as diabetes, atherosclerosis, and osteoporosis are becoming more and more of a threat to public health. Mimicking physical workout, precise blocking of the physiological processes or in combination will eventually lead to innovative drugs for treatment of the diseases.
Marine invertebrates, such as sponges, have been known to be the richest source of bioactive natural products. Nearly 30% of marine natural products discovered so far have been isolated from sponges alone. Marine sponges contain diverse microorganisms such as archaea, bacteria, cyanobacteria, algae, phytoplankton and fungi in the inner tissues up to 50% of dry weight. Recently microbial symbionts of sponges were demonstrated to be the real producers of bioactive natural products isolated from marine sponges and can be regarded as an untapped resource for innovative drug discovery. We established diverse libraries of marine invertebrates and their symbiotic microorganisms for facilitating discovery of novel bioactive compounds.