专职教师/共建团队PI
李朝政
教授/研究员
单位:海洋生物养殖与环境研究所 行政职务:
学科专业:海洋生物学 专业技术资格/导师:特聘研究员
办公电话:020-39332850
电子邮箱:lichzh5@mail.sysu.edu.cn
通讯地址:广州大学城中山大学生科楼201

研究方向

水产动物病害发病的分子机理及病害防控理论

个人详细介绍

(一教育背景

1. 2008/09 – 2013/06:中山大学,生命科学学院,海洋生物学专业,博士(硕博连读)

2. 2004/09 – 2008/06:中南林业科技大学,生命科学学院,生物技术专业,学士

(二)工作经历

1. 2013/06 – 2015/07:中山大学,生命科学学院,博士后

2. 2015/08 – 至今:中山大学,海洋学院,特聘研究员

(三授权发明专利

1. 凡纳滨对虾EST微卫星标记的特异引物及其应用,李朝政吕玲张付霞翁少萍何建国,授权时间:2012.09,中国,授权专利号:ZL201010259991.7

2. 一种凡纳滨对虾fx5微卫星DNA标记鉴定fx5遗传变异图谱的方法,李朝政吕玲翁少萍何建国,授权时间:2013.05,中国,授权专利号:ZL 201010258780.1

(四)主持及参与的科研项目

(1)主持的项目

1.广东省特支计划青年拔尖人才项目:30万;

2.广东省自然科学基金杰出青年基金:对虾中核酸诱导抗病毒免疫反应的分子机制,100万;

3.国家自然科学基金-青年科学基金项目:白斑综合症病毒对凡纳滨对虾NF-κB调控的分子机制,25万

4.广东省海洋与渔业局项目:凡纳滨对虾SSR分子标记辅助育种设计,50万;

5.高校基本科研业务费中山大学青年教师培育项目:环境胁迫诱发白斑综合症爆发的分子机制,15万;

6.中国博士后科学基金-面上资助项目(第55批):凡纳滨对虾IRFLvIRF)基因克隆、鉴定及功能研究,5万

(2)参与的项目

1.国家自然科学基金面上项目:凡纳滨对虾Vago信号通路的调控机制及其在抗病毒免疫中的作用,78万;

2.国家自然科学基金青年基金:鲈鱼RLRs信号通路在鱼类神经坏死病毒感染过程中的作用机制研究,25万;

3. 农业部“引进国际先进农业科学技术”项目:中南美洲农业生物资源引进与农业技术需求和政策信息收集研究,200万;

4.广东省水产良种体系建设方向项目:南美白对虾良种选育,80万;

5.中国 - 东盟海上合作基金项目:中国-东盟海水养殖技术联合研究与推广中心,3641.41万;

6.国家自然科学基金重点项目:凡纳滨对虾白斑综合症生物防控机理,260万;

7.国家虾产业技术体系项目(2011-2016),500万;

8.广东省-厄瓜多尔对虾养殖技术联合推广中心,50万。

(五代表性论文

1.Identification of two p53 isoforms from Litopenaeus vannamei and their interaction with NF-κB to induce distinct immune response. Scientific Reports. 2017.  Haoyang Li, Sheng Wang, Yonggui Chen, Kai Lǚ, Bin Yin, Sedong Li, Jianguo He*, Chaozheng Li * (*: Correspondence-author).

2. An invertebrate STING from shrimpactivates an innate immune defenseagainst bacterial infection. FEBS Letters, 2017 Haoyang Li, Sheng Wang, Kai Lǚ, Bin Yin, Bang Xiao, Sedong Li, Jianguo He*, Chaozheng Li* (*: Correspondence-author).

3.Identificationand functional analysis of a TEP gene from a crustacean reveals its transcriptionalregulation mediated by NF-κB and JNK pathways and its broad protective rolesagainst multiple pathogens. Developmental and Comparative Immunology, 2017, ChaozhengLi*, Haoyang Li, Bang Xiao, Yonggui Chen, Sheng Wang, Kai Lǚ, Bin Yin, Sedong Li, Jianguo He*. (*: Correspondence-author).

4. Shrimp with knockdown of LvSOCS2, a negative feedback loop regulator of JAK/STAT pathway in Litopenaeus vannamei, exhibit enhanced resistance against WSSV(2016) Developmental and Comparative Immunology, 65, pp. 289-298. Wang, S., Song, X., Zhang, Z., Li, H., Lǚ, K., Yin, B., He, J*., Li, C*.(*: Correspondence-author)

5. Cloning, identification and functional analysis of a β-catenin homologue from Pacific white shrimp, Litopenaeus vannamei (2016) Fish and Shellfish Immunology, 54, pp. 411-418. Zhang, S., Shi, L., Lü, K., Li, H., Wang, S., He, J., Li, C*. (*: Correspondence-author)

6. Molecular cloning, characterization and expression analysis of Wnt4, Wnt5, Wnt6, Wnt7, Wnt10 and Wnt16 from Litopenaeus vannamei. (2016) Fish and Shellfish Immunology, 54, pp. 445-455. Zhang, S., Li, C.-Z., Yang, Q.-H., Dong, X.-H., Chi, S.-Y., Liu, H.-Y., Shi, L.-L., Tan, B.-P*.

7. Identification and characterization of transforming growth factor β-activated kinase 1 from Litopenaeus vannamei involved in anti-bacterial host defense (2016) Fish and Shellfish Immunology, 52, pp. 278-288. Wang, S., Li, H., Lü, K., Qian, Z., Weng, S., He, J.*, Li, C*. (*: Correspondence-author)

8. MKK6 from pacific white shrimp Litopenaeus vannamei is responsive to bacterial and WSSV infection (2016) Molecular Immunology, 70, pp. 72-83. Li, H., Wang, S., Qian, Z., Wu, Z., Lü, K., Weng, S., He, J., Li, C.

9.Identification and characterization of MKK7 as an upstream activator of JNK in Litopenaeus vannamei (2016) Fish and Shellfish Immunology, 48, pp. 285-294. Wang, S., Qian, Z., Li, H., Lü, K., Xu, X., Weng, S., He, J*., Li, C*.(*: Correspondence-author)

10. Activation of Vago by interferon regulatory factor (IRF) suggests an interferon system-like antiviral mechanism in shrimp. ChaozhengLi, Haoyang Li, Yixiao Chen, Yonggui Chen, Sheng Wang, Shaoping Weng, Xiaopeng Xu*, Jianguo He*(*: Correspondence-author). Scientific Reports, 5:15078

11. Analysis of Litopenaeus vannamei transcriptome using the next-generation DNA sequencing technique. ChaozhengLi, Shaoping Weng, Yonggui Chen, Xiaoqiang Yu, Ling Lv, Haiqing Zhang, Jianguo He*, Xiaopeng Xu*(*: Correspondence-author). PLoS ONE, 2012, 7:e47442.

12. Presence of Tube isoforms in Litopenaeus vannamei suggests various regulatory patterns of signal transduction in invertebrate NF-kappaB pathway. ChaozhengLi, Yixiao Chen, Shaopeng Weng, Sedong Li, Hongliang Zuo, Xiaoqiang Yu, Haoyang Li, Jianguo He*, Xiaopeng Xu* (*: Correspondence-author). Developmental and Comparative Immunology, 2014, 42:174-85.

13. Identification, characterization, and function analysis of the Cactus gene from Litopenaeus vannamei. ChaozhengLi #, Yixiao Chen#, Shuang Zhang, Ling Lv, Yihong Chen, Jiaoting Chai, Shaoping Weng, Yonggui Chen, Jianguo He*, Xiaopeng Xu*(#:Co-first; *: Correspondence-author). PLoS ONE, 2012, 7:e49711.

14. Pellino protein from pacific white shrimp Litopenaeus vannamei positively regulates NF-κB activation. ChaozhengLi, Jiaoting Chai, Haoyang Li, Hongliang Zuo, Sheng Wang, Wei Qiu, Shaoping Weng,Jianguo He*, Xiaopeng Xu*(*: Correspondence-author). Developmental and Comparative Immunology, 2014, 44: 341-350.

15. The c-Fos and c-Jun from Litopenaeus vannamei play opposite roles in Vibrio parahaemolyticus and white spot syndrome virus infection. ChaozhengLi *, Haoyang Li, Sheng Wang, Xuan Song, Zijian Zhang, Zhe Qian, Hongliang Zuo, Xiaopeng Xu, Shaoping Weng, Jianguo He*(*: Correspondence-author).Developmental and Comparative Immunology 2015 52: 26–36.

16. A Janus Kinase in the JAK/STAT signaling pathway from Litopenaeus vannamei is involved in antiviral immune response. Xuan Song#, Zijian Zhang#, Sheng Wang, Haoyang Li, Hongliang Zuo, Xiaopeng Xu, Shaoping Weng, Jianguo He*, ChaozhengLi *(#:Co-first; *: Correspondence-author). Fish & shellfish immunology. 2015 44:662-73.

17. A C-type lectin (LvCTL4) from Litopenaeus vannamei is a downstream molecule of the NF-kappaB signaling pathway and participates in antibacterial immune response. Haoyang Li#, Yonggui Chen#, Ming Li, Sheng Wang, Hongliang Zuo, Xiaopeng Xu, Shaoping Weng, Jianguo He*, ChaozhengLi*(#:Co-first; *: Correspondence-author). Fish & shellfish immunology. 2015 43:257-63.

18. Identification and functional characterization of the TAB2 gene from Litopenaeus vannamei. Sheng Wang, Haoyang Li, Zhe Qian, Xuan Song, Zijian Zhang, Hongliang zuo, Xiaopeng Xu, Shaoping Weng, Jianguo He*, ChaozhengLi*(*: Correspondence-author). Fish & shellfish immunology. 2015 46:206-216.

19. Identification of a C-type lectin with antiviral and antibacterial activity from pacific white shrimp Litopenaeus vannamei.Ming Li#, ChaozhengLi #, Chunxia Ma, Haoyang Li, Hongliang Zuo, Shaoping Weng, Xiaohan Chen, Digang Zeng, Jianguo He*, Xiaopeng Xu* (#:Co-first; *: Correspondence-author). Developmental and Comparative Immunology 2014 46: 231–240.

20. Identification of a JAK/STAT pathway receptor domeless from Pacific white shrimp Litopenaeus vannamei. Muting Yan#, ChaozhengLi #, Ziqi Su, Qianhui Liang, Haoyang Li, Shizhong Liang, Shaoping Weng, Jianguo He*, Xiaopeng Xu* (#:Co-first; *: Correspondence-author).  Fish & Shellfish Immunology 2015 44: 26-32.