专职教师/共建团队PI
陈碧双
副教授/副研究员
单位:海洋生物天然产物研究所 行政职务:
学科专业:海洋微生物催化与转化 专业技术资格/导师:特聘副研究员
办公电话:
电子邮箱:chenbsh23@mail.sysu.edu.cn
通讯地址:中山大学东校区南实验楼E203

研究方向

海洋微生物催化与转化

招生专业

海洋生物学,海洋化学

个人详细介绍

1. 教育经历

   2004.9—2008.7 中山大学,  材料化学,  本科,  学士学位

   2008.9—2011.7 厦门大学,  有机化学,  硕士研究生,  硕士学位,导师:黄培强 教授,叶剑良副教授

   2011.8—2015.9 荷兰代尔夫特理工大学 (Delft University of Technology),  生物催化,  博士研究    

                              生,  博士学位,导师:Prof. Ulf Hanefeld

2. 工作经历

    2015.10-至今 中山大学 海洋学院 特聘副研究员


3.研究方向

海洋微生物催化与转化


4. 代表性期刊论文

  1. Chen B-S#, Médici R#, van der Helm MP, van Zwet Y, Gjonaj L, van Der Geest R, OttenLG,

    Hanefeld U (2018) Rhodococcus strains as source for ene-reductase activity. Applied Microbiology and Biotechnology,doi:10.1007/s00253-018-8984-7.

  2. Liu H,  Duan W-D, de Souza FZR, Liu L,Chen B-S*, (2018) Asymmetric Ketone Reductionby Immobilized Rhodotorula Mucilaginosa. Catalysts, 8, 165; doi:10.3390/catal8040165.

  3. Liu H,  Chen B-S*, de Souza FZR, Liu L (2018) A Comparative Study on Asymmetric Reduction of Ketones Using the Growing and Resting Cells of Marine-Derived Fungi. Marine Drugs 16:62.

  4. Liu H, de Souza FZR, Liu L, Chen B-S*, (2018) The use of marine-derived fungi for preparation of enantiomerically purealcohols. Applied Microbiology and Biotechnology 102:1317–1330 .

  5. Li F, Lin Z-F, Wen J-S, Wei Y-S, Gan H-Y, He H-J, Lin J-Q, Xia Z, Chen B-S*, Guo W-J, Tan C-S, Cai H-Y.   (2017). Risk assessment of trace metal-polluted coastal sediments on Hainan Island:
    A fullscale set of 474 geographical locations covering the entire island. Marine Pollution Bulletin,
    125:541-555.

  6. Chen B-S, Liu H, deSouza FZR, Liu L (2017). Organic solvent-tolerant marine microorganisms as catalystsfor kinetic resolution of cyclic β-hydroxykKetones. Marine Biotechnology, 19:351-360.

  7. Chen B-S, Otten LG,Hanefeld U (2015) Stereochemistry of enzymatic water addition to C = C bonds,Biotechnology Advances 33: 526-546.

  8. Chen B-S, Resch V,Otten, LG, Hanefeld U (2015) Enantioselective Michael addition of water, Chemistry-AEuropean Journal 21: 3020-3030.

  9. Chen B-S,  Hanefeld U (2013) Enantioselective preparation of (R)- and(S)-3-hydroxycyclopentanone by kinetic resolution, Journal of MolecularCatalysis B: Enzymatic 85: 239-242.

  10. Chen B-S, Otten LG,Resch V,  Muyzer G, Hanefeld U (2013)Draft genome sequence of Rhodococcus rhodochrous ATCC 17895, Standards in GenomicSciences 9: 175-184.

  11. Chen B-S, Yang L-H, Ye J-L,Huang T, Ruan Y-P, Fu J, Huang P-Q (2011) Diastereoselective synthesis andbioactivity of long-chain anti-2-amino-3-alkanols, European Journal ofMedicinal Chemistry 46: 5480-5486.

  12. Chen B-S, Jin J, ReschV, Hanefeld U. Enantioselective Michael addition of water using Rhodococcus rhodochrousATCC 17895. In: Whittal J., Sutton P., Kroutil W.(eds), Practical Methods inBiocatalysis and Biotransformations, Wiley-VCH; 2016, Chapter 4, 106-112.

  13. ReschV, Seidler C, Chen B-S, Degeling C,Hanefeld U (2013) On the  Michaeladdition of water to α,β-unsaturated ketones using amino acids, EuropeanJournal of Organic Chemistry 7697-7704.

  14. ReschV, Jin J,  Chen B-S, Hanefeld U (2014) Michaelhydratase alcohol dehydrogenase or just alcohol dehydrogenase?  AMB Express, 4: 30-36.

5. 主持项目

  1. 高校基本科研业务费中山大学青年教师培育项目:15万,执行年限:2017.1-2019.12

  2. 广东省自然科学基金博士启动项目:10万,执行年限:2017.5-2020.4

  3. 国家自然科学基金青年基金项目:25 万,执行年限:2018.01-2020.12


6. 专利

1. 陈碧双,刘岚,刘慧,杨振男,白地霉菌株不对称催化还原卤代芳香酮的方法,2017,CN107418981A

2. 陈碧双,刘岚,刘慧,杨振男,一种烯键还原酶及其制备和应用,2017,CN106906226A.

3. 黄培强, 傅瑾 ( 第一第二作者为指导老师 ), 陈碧双, 杨隆河, 叶剑良,邻氨基醇类化合物及其制备方法与应用, 2011,  CN102241596A.